ODCs

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1 OMIM reference -
2 associated genes
10 signs/symptoms

PROTEIN INTERACTIONS: 1

3 OMIM references -
2 associated genes
No signs/symptoms info

Lethal acantholytic epidermolysis bullosa

Autosomal dominant medullary cystic kidney disease with or without hyperuricemia

DSP	(UniProt - OMIM)		MUC1	(UniProt - OMIM)
JUP	(UniProt - OMIM)		UMOD	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	JUP	(0.85)	MUC1

Citations in the biomedical literature:

Lethal acantholytic epidermolysis bullosa		Autosomal dominant medullary cystic kidney disease with or without hyperuricemia
	Synonym(s): - LAEB		Synonym(s): - Autosomal dominant nephronophthisis

	Classification (Orphanet): - Rare genetic disease - Rare skin disease		Classification (Orphanet): (no data available)

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: before age 5 Type of inheritance: autosomal recessive		Epidemiological data: Class of prevalence: 1-9 / 1 000 000 Average age onset: adulthood Average age of death: - Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - 1 MeSH reference: C535493		External references: 3 OMIM references - No MeSH references

Lethal acantholytic epidermolysis bullosa
	Very frequent - Absent / small fingernails / anonychia of hands - Alopecia - Autosomal recessive inheritance - Chronic skin infection / ulcerations / ulcers / cancrum - Early death / lethality - Enanthema / aphtosa / aphta / leukoplakia - Premature eruption of teeth / natal teeth - Vesicles / bullous / exsudative lesions / bullous / cutaneous / mucosal detachment Occasional - Cardiomyopathy / hypertrophic / dilated - Epigastralgia / heartburn / gastric / duodenal ulcer / gastritis
Autosomal dominant medullary cystic kidney disease with or without hyperuricemia
(no data available)